Objective: To investigate and analyze the current status of drug manipulation for pediatric oral dosing in China

to understand the categories and specifications of the most frequent drug manipulation in clinic

so as to provide suggestions for improving the current status of drug manipulation. Methods: Questionnaire survey was used to collect the medical orders of oral drugs for children from 30 hospitals in China in Dec. 2019

and statistical analysis was performed in terms of drug categories

number of medical orders

specifications of drug manipulation and most urgent needs

etc. Results: Totally 16 categories

282 kinds of drug manipulation for pediatric oral dosing were collected. The most frequently categories of drug manipulation for pediatric oral dosing were anti-infective drugs

digestive system drugs and cardiovascular system drugs. The most frequently drugs of drug manipulation for pediatric oral dosing were spironolactone tablets

potassium chloride tablets and furosemide tablets. The most frequently specifications of drug manipulation for pediatric oral dosing were 1/2

1/4 and 1/5

the specifications of 1/2

1/3

1/4 and 1/5 were most commonly wanted. Spironolactone tablets

furosemide tablets and other 7 kinds of drugs not only had a large workload in drug manipulation

but the minimum drug manipulation specification was less than or equal to 1/20. Conclusion: The widespread phenomenon of drug manipulation for pediatric oral dosing reflects the lack of appropriate drugs for children in China. In order to ensure the safety

effectiveness and accessibility of drugs for children

the work of drug manipulation requires the cooperation of government

enterprises

universities

research institutions and hospitals.